Methods and compositions for detecting and treating mycobacterial infections using an INHA gene
AssigneeAgResearch, New Zealand Pastoral Agriculture Research Institute Ltd.
InventorsWilliam R. Jacobs, Jr., Desmond Michael Collins, Asesh Banerjee, Geoffrey William de Lisle, Theresa Mary Wilson
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Abstract
The embodiments of the invention are based upon the identification and characterization of genes that determine mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. These genes, termed inhA, encode a polypeptide, InhA, that is the target of action of mycobacteria for isoniazid. The sequences of wild-type INH-sensitive as well as allelic or mutant INH-resistant inhA genes and their operons are provided. Also provided are isolated InhA polypeptides of both the INH-resistant and INH-sensitive types.
Claims13
An isolated polynucleotide comprised of a sequence encoding a mycobacterial InhA polypeptide, wherein the polypeptide has at least 80% sequence identity to the mycobacterial polypeptide encoded in SEQ ID NO:1 and is involved in mycolic acid biosynthesis.
An isolated polynucleotide comprised of a sequence encoding a mycobacterial InhA polypeptide, wherein the polypeptide has at least 80% sequence identity to the mycobacterial polypeptide encoded in SEQ ID NO:3 and is involved in mycolic acid biosynthesis.
Dependencies are inferred from the claim text.