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US 5,686,589 AGranted
Esters and amides of substituted phenyl and pyridyl amino carboxylates
AssigneesCell Pathways, Inc., University of Arizona
InventorsKlaus Brendel, Paul Gross, Rifat Pamukcu
Life of this patent
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Abstract
Esters and amides of substituted phenyl and pyridyl amino carboxylates are useful in the treatment of colonic polyps.
Claims11
A compound of the formula:
- ##STR7## where Y is CH or N;
- R.sub.1 represents one or more substituents that are each attached to the aromatic ring independently selected from the group consisting of lower alkyl, lower haloalkyl, halo, alkoxy or benzyloxy;
- Q is the deprotonated residue of a polymeric or macromolecular structure having a molecular weight of at least 1000 containing at least primary and/or secondary amino groups and/or hydroxy groups;
- and
- n is an integer of at least 2.
2 more elements
A method for treating patients having colonic polyps to reduce said polyps which comprises administering to said patient a therapeutically effective amount of a compound of the formula:
- ##STR8## where Y is CH or N;
- R.sub.1 represents one or more substituents that are each attached to the aromatic ring independently selected from the group consisting of lower alkyl, lower haloalkyl, halo, alkoxy or benzyloxy;
- Q is the deprotonated residue of a polyamine or polyhydroxy compound;
- and
- n is an integer of at least 2.
2 more elements
Dependencies are inferred from the claim text.