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US 5,686,578 AGranted
Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
AssigneeImmunomedics, Inc.
InventorDavid M. Goldenberg
Life of this patent
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Abstract
Polyspecific immunoconjugates and antibody composites that bind a multidrug transporter protein and an antigen associated with a tumor or infectious agent are used to overcome the multidrug resistant phenotype. These immunoconjugates and composites also can be used diagnostically to determine whether the failure of traditional chemotherapy is due to the presence of multidrug resistant tumor cells, multidrug resistant HIV-infected cells or multidrug resistant infectious agents.
Claims14
A polyspecific immunoconjugate comprising:
- (a) at least one antibody component that binds with a first epitope of a multidrug transporter protein;
- (b) at least one antibody component that binds with a first epitope of an antigen, wherein said antigen is associated with a tumor or an infectious agent;
- and
- (c) at least one diagnostic or therapeutic agent.
1 more element
Dependencies are inferred from the claim text.