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US 5,686,577 AGranted
T cell factors influencing B cell development
AssigneeCornell Research Foundation, Inc.
InventorsMarc E. Weksler, Paul Szabo
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AssigneeCornell Research Foundation, Inc.
InventorsMarc E. Weksler, Paul Szabo
Estimating the term…
The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further provides an isolated DNA molecule encoding the protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The isolated DNA molecule can be inserted as a heterologous DNA in an expression vector forming a recombinant DNA expression system for producing the protein or polypeptide. Likewise, the heterologous DNA can be incorporated in a cell to achieve this objective. The isolated protein or polypeptide of the present invention can be combined with a pharmaceutically-acceptable carrier or used alone for administration to mammals for activating production of B cells.
An isolated protein or polypeptide produced by T cells and having a molecular weight of about 17.5-18.5 kilodaltons, wherein said isolated protein or polypeptide activates production of B cells, activates one or more recombinase activation gene(s), activates rearrangement and expression of variable region gene segments in B cells, and generates a diverse repertoire of B cells.
Dependencies are inferred from the claim text.