Malignant cell type markers of the interior nuclear matrix
AssigneeMatritech, Inc.
InventorsGary Toukatly, Graham P. Lidgard
Life of this patent
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Abstract
Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
Claims9
An isolated protein produced by expression in a host cell of recombinant DNA, said protein comprising an amino acid sequence encoded by the DNA of Seq. ID No. 1 or an amino acid sequence variant thereof, wherein said variant is characterized as
- (a) being encoded by a nucleic acid sequence that hybridizes under stringent hybridization conditions with a nucleic acid sequence complementary to the DNA of Seq. ID No. 1, and
- (b) having an epitope which binds an immunoglobulin that binds the amino acid sequence encoded by the DNA of Seq. ID No. 1.
An isolated protein produced by expression in a host cell of recombinant DNA, said protein comprising an amino acid sequence encoded by Seq. ID No. 3 or an amino acid sequence variant thereof, wherein said variant is characterized as
- (a) being encoded by a nucleic acid sequence that hybridizes under stringent hybridization conditions with a nucleic acid sequence complementary to the DNA of Seq. ID No. 3, and
- (b) having an epitope which binds an immunoglobulin that binds the amino acid sequence encoded by Seq. ID NO. 3.
Dependencies are inferred from the claim text.