Pharmaceutical preparations for ameliorating epigastric functional disorders

A method for treating epigastric dysfunction complaints comprising administering to a vertebrate afflicted with said complaints an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR13## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.

A method for regulating digestive tract motility comprising administering to a vertebrate having abnormal digestive tract motility an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR14## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.

A method for regulating gastric motility comprising administering to a vertebrate having abnormal gastric motility an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR15## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.

A method for accelerating gastric motility comprising administering to a vertebrate in need of accelerated gastric motility an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR16## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.

A method for regulating gastric emptying comprising administering to a vertebrate having abnormal gastric emptying an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR17## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.

A method for accelerating gastric emptying comprising administering to a vertebrate in need of accelerated gastric emptying an effective amount of an aminobenzamide compound represented by the following formula (1) or a salt thereof:

• ##STR18## wherein each of R.sup.1 and R.sup.2 is independently a lower alkoxyl group;
• R.sup.3 is a hydrogen atom, a lower acyl group, a lower alkyl group, a lower alkoxycarbonyl group or a group represented by a formula --X--SO.sub.3 M, where X is a lower alkylene group and M is an alkalimetal or an alkaline earth metal;
• R.sup.4 is a hydrogen atom, a halogen atom or a lower alkoxy group;
• R.sup.5 is an amino group, a morpholino group or a lower alkylamino group, where the alkyl moiety of said lower alkylamino group may have a hydroxyl group;
• and n is an integer of 1 to 6.