Endothelin receptor antagonists

A compound of the formula (I) ##STR24## wherein:

• R.sub.1 is --X(CH.sub.2).sub.n Ar or --X(CH.sub.2).sub.n R.sub.8 or ##STR25## R.sub.2 is Ar or (c);
• P.sub.1 is --X(CH.sub.2).sub.n R.sub.8 ;
• P.sub.2 is --X(CH.sub.2).sub.n R.sub.8, or --XR.sub.9 Y;
• R.sub.3 and R.sub.5 are independently hydrogen, R.sub.11, OH, C.sub.1-8 alkoxy, S(O).sub.q R.sub.11, N(R.sub.6).sub.2, Br, F, I, Cl, CF.sub.3, NHCOR.sub.6, --R.sub.11 CO.sub.2 R.sub.7, --XR.sub.9 --Y, XY or --X(CH.sub.2).sub.n R.sub.8 wherein the methylene groups of --X(CH.sub.2).sub.n R.sub.8 may be unsubstituted or substituted by one or more --(CH.sub.2).sub.n Ar groups;
• R.sub.4 is hydrogen, Ar, R.sub.11, OH, C.sub.1-5 alkoxy, S(O).sub.q R.sub.11,N(R.sub.6).sub.2, --X(R.sub.11), Br, F, I, Cl or NHCOR.sub.6 wherein the C.sub.1-5 alkoxy may be unsubstituted or substituted by OH, methoxy or halogen;
• R.sub.6 is independently hydrogen or C.sub.1-4 alkyl;
• R.sub.7 is independently hydrogen, C.sub.1-6 alkyl or (CH.sub.2).sub.n Ar;
• R.sub.8 is hydrogen, R.sub.11, CO.sub.2 R.sub.7, CO.sub.2 C(R.sub.7).sub.2 O(CO)XR.sub.7, --N(R.sub.7)SO.sub.2 R.sub.7, PO.sub.3 (R.sub.7).sub.2 ;
• SO.sub.2 NR.sub.7 R.sub.11, CONR.sub.7 SO.sub.2 R.sub.11, SO.sub.3 R.sub.7 SO.sub.2 R.sub.7, SO.sub.3 R.sub.7, SO.sub.2 R.sub.7, P(O)(OR.sub.7)R.sub.7, CN --C(O)N(R.sub.6).sub.2, tetrazole or OR.sub.6 ;
• R.sub.9 is monovalent or divalent C.sub.1-10 alkyl, C.sub.2-10 alkenyl or phenyl all of which may be unsubstituted or substituted by one or more OH, N(R.sub.6).sub.2, COOH, halogen or XC.sub.1-5 alkyl;
• R.sub.10 is R.sub.3 or R.sub.4 ;
• R.sub.11 is monovalent or divalent C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl all of which may be unsubstituted or substituted by one or more OH, CH.sub.2 OH, N(R.sub.6).sub.2 or halogen;
• X is (CH.sub.2).sub.n, O, NR.sub.6 or S(O).sub.q ;
• Y is CH.sub.3 or X(CH.sub.2).sub.n Ar;
• Ar is:
• ##STR26## naphthyl, indolyl, pyridyl, thienyl, oxazolidinyl, oxazolyl, thiazolyl, is othiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, pyrrolyl, or pyrimidyl;
• all of which may be unsubstituted or substituted by one or more R.sub.3 or R.sub.4 groups;
• A is C.dbd.O, or (C(R.sub.6).sub.2).sub.m ;
• B is --CH.sub.2 -- or --O--;
• q is zero, one or two;
• n is an integer from 0 to six;
• m is 1, 2 or 3;
• and the dotted line indicates the optional presence of a double bond;
• or a pharmaceutically acceptable salt thereof;
• provided that when the optional double bond is present there is no P.sub.1 or R.sub.10 ;
• and further provided that X is not oxygen for R.sub.1.