Inhibitors of farnesyl-protein transferase

A compound which inhibits farnesyl-protein transferase of the formula III:

• ##STR15## wherein:
• R.sup.1 is hydrogen, an alkyl group, an aralkyl group an acyl group, an aracyl group, an aroyl group, an alkylsulfonyl group, aralkylsulfonyl group or arylsulfonyl group, wherein alkyl and acyl groups comprise a straight chain or branched chain hydrocarbons of 1 to 6 carbon atoms;
• R.sup.2, R.sup.3 and R.sup.5 are independently selected from
• a) a side chain of naturally occurring amino acids;
• b) a side chain of oxidized forms of naturally occurring amino acids which comprise:
• i) methionine sulfoxide or
• ii) methionine sulfone;
• or
• c) a substituted or unsubstituted aliphatic, aromatic or heteroaromatic group, which comprises allyl, cyclohexyl, phenyl, pyridyl, imidazolyl or branched or unbranched saturated chains of 2 to 8 carbon atoms, wherein the substituted aliphatic group is substituted with an aromatic or heteroaromatic ring;
• R.sup.4 is hydrogen or an alkyl group, wherein the alkyl group comprises straight chain or branched chain hydrocarbons of 1 to 6 carbon atoms;
• T is O or S(O).sub.m ;
• m is 0, 1 or 2;
• or the pharmaceutically acceptable salts thereof.