2, 3-substituted pyridines for the treatment of inflammation

A compound of Formula I ##STR47## wherein R.sup.1 is selected from hydrido, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, aryl, alkylthio, alkylamino, aralkoxy, aralkylthio, aralkylamino, N-alkyl-N-aralkylamino, cycloalkylalkoxy, cycloalkylalkylthio, N-alkyl-N-cycloalkylalkylamino, azido, arylcarbonylalkoxy, arylcarbonylthio, alkoxycarbonylalkoxy, alkylaminocarbonylalkoxy, alkoxycarbonylalkylthio, alkylaminocarbonylalkylthio, arylcarbonylalkylamino, alkoxycarbonylalkylamino, allylthio, allylamino, N-alkyl-N-allylamino, arylallyloxy and allyloxy;

• wherein R.sup.2 is cyano;
• and
• wherein R.sup.3 and R.sup.4 are independently selected from aryl 2-pyridyl,-3-pyridyl and 4pyridyl, wherein R.sup.3 and R.sup.4 are optionally substituted at a substitutable position with one or more radicals independently selected from hydrido, alkyl, cyano, carboxyl, alkoxycarbonyl, haloalkyl, hydroxyl, hydroxyalkyl, haloalkoxy, alkoxyalkyl, alkylsulfinyl, halo, alkylsulfonyl, aminosulfonyl, haloalkylsulfonyl, alkoxy and alkylthio;
• provided one of R.sup.3 and R.sup.4 is phenyl substituted with methylsulfonyl, aminosulfonyl, or haloalkylsulfonyl;
• or a pharmaceutically-acceptable salt thereof.