Tricyclic condensed heterocyclic compounds their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsGiichi Goto, Yuji Ishihara, Keisuke Hirai
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Abstract
A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n represents an integer from 2 to 10; R.sup.1 represents H or an optionally substituted hydrocarbon group, which may be different from one another in the repetition of n; and Y represents an optionally substituted 4-piperidinyl, 1-piperazinyl or 4-benzyl-1-piperidinyl group, or a salt thereof, inhibiting excellent cholinesterase inhibitory activity and monoamine reuptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.
Claims9
A compound of the formula (I):
- ##STR1483## wherein Ar is a group of the formula:
- ##STR1484## wherein R.sup.6 is (1) hydrogen, (2) a C.sub.1-6 alkyl, phenyl-C.sub.1-4 alkyl, C.sub.1-6 alkyl-carbonyl, benzoyl, C.sub.1-6 alkoxy-carbonyl or mono- or di-C.sub.1-4 alkyl-carbamoyl group which may be substituted with 1 or 2 substituents selected from the group consisting of halogen, nitro, C.sub.1-4 alkoxy and hydroxy, (3) formyl or (4) carbamoyl;
- and ring B or C may be substituted with an oxo or C.sub.1-6 alkyl;
- n is an integer of 2 to 10;
- R.sup.1 is hydrogen;
- and
- Y is a 4-piperidinyl or 1-piperazinyl group which is substituted by benzyl;
- or a pharmaceutically acceptable salt thereof.
A compound selected from 1-(1,2,2a,3,4,5-hexahydrobenz(cd)indol-6-yl)-3-(1-(phenylmethyl)piperidin- 4-yl)-1-propanone and 1-(6,7-dihydro-5H-dibenz(c,e)azepin-3-yl)-3-(4-(phenylmethyl)-1-piperaziny l)-1-propanone.
Dependencies are inferred from the claim text.