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US 5,686,465 AGranted
Sex steroid activity inhibitors
AssigneeEndorecherche, Inc.
InventorsFernand Labrie, Yves Merand
Life of this patent
Estimating the term…
Abstract
Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment of breast cancer or other diseases whose progress is aided by activation of sex steroid receptors.
Claims5
A compound whose molecular structure is:
- ##STR104## wherein the dotted line is an optional pi bond and Z is --O--, --NH--, --S-- or --CH.sub.2 --;
- wherein R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, hydroxyl and a moiety convertible in vivo to hydroxyl and are not simultaneously hydrogen and are not simultaneously at position 3 and position 12;
- wherein R.sup.7 is methyl, ethyl, propyl ethenyl or ethynyl;
- and
- wherein R.sup.1 is selected from the group consisting of --(CH.sub.2).sub.10 CONCH.sub.3 C.sub.4 H.sub.9, --(CH.sub.2).sub.6 NC.sub.5 H.sub.10, --(CH.sub.2).sub.9 SOC.sub.5 H.sub.6 F.sub.5, and .phi.--O--(CH.sub.2).sub.2 NC.sub.5 H.sub.10.
2 more elements
Dependencies are inferred from the claim text.