Indole derivatives
AssigneeGlaxo Wellcome Inc.
InventorsAlfredo Cugola, Giovanni Gaviraghi, Fabrizio Micheli
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Abstract
The invention relates to compounds of formula (I). ##STR1## or a salt, or metabolically labile ester thereof wherein R.sub.1 represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.3 or COR.sub.3 wherein R.sub.3 represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2; A represents an ethynyl group or an optionally substituted ethenyl group; X represents a bond or a C.sub.1-4 alkylene chain; R.sub.2 represents a bridged cycloalkyl or bridged heterocyclic group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.
Claims10
A compound of formula (I) ##STR7## or a salt, or metabolically labile ester thereof wherein R.sub.1 represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.3 or COR.sub.3 wherein R.sub.3 represents hydroxy, methoxy, or amino;
- m is zero or an integer 1 or 2;
- A represents an ethynyl group or an optionally substituted ethenyl group;
- X represents a bond or a C.sub.1-4 alkylene chain;
- R.sub.2 represents a bridged cycloalkyl or bridged heterocyclic group.
The compounds selected from the group consisting of:
- (E)-32-(1-adamantylcarbamoyl)ethenyl!4,6-dichloroindole-2-carboxylic acid;
- and
- (E) 3-2'-(noradamantyl-3"-aminocarbonyl) ethenyl!-4,6-dichloroindole-2-carboxylic acid and physiologically acceptable salts thereof or metabolically labile esters thereof.
Dependencies are inferred from the claim text.