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US 5,686,460 AGranted
Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics
AssigneeLaboratoires UPSA
InventorsEric Nicolai, Michele Launay, Dominique Potin, Jean-Marie Teulon
Life of this patent
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Abstract
The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
Claims17
A carbocyclic diarylmethylene compound of formula (I):
- ##STR15## in which:
- the ring A is:
- a phenyl ring, or,
- a pyridyl ring;
- the ring B is a ring containing five carbon atoms:
- which is saturated or
- unsaturated, in which case R.sub.2 and/or R.sub.4 are absent in order to respect the valencies of the carbon atom;
- X.sub.1 and X.sub.2 independently are:
- the hydrogen atom,
- a halogen atom,
- a hydroxyl group,
- a lower alkyl radical having 1 to 6 carbon atoms,
- a trifluoromethyl radical,
- a lower O-alkyl radical having 1 to 6 carbon atoms, or
- a radical NR.sub.5 R.sub.6,
- or else X.sub.1 and X.sub.2 are a methylenedioxy group;
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are:
- the hydrogen atom,
- a halogen atom,
- a lower alkyl radical having 1 to 6 carbon atoms, or
- a lower haloalkyl radical having 1 to 6 carbon atoms,
- R.sub.5 and R.sub.6 independently are:
- a lower alkyl radical having 1 to 6 carbon atoms or
- the hydrogen atom;
- and
- R is:
- a lower alkyl radical having 1 to 6 carbon atoms,
- a lower haloalkyl radical having 1 to 6 carbon atoms, or
- a group NH.sub.2.
26 more elements
Dependencies are inferred from the claim text.