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US 5,686,456 AGranted
Methods of treating pneumocystis carinii pneumonia
AssigneesUniversity of North Carolina, Georgia State University Research Foundation, Inc., Auburn University
InventorsDavid W. Boykin, Christine C. Dykstra, Richard R. Tidwell, James E. Hall, W. David Wilson, Arvind Kumar
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Abstract
The present invention provides methods for treating Pneumocystis carinii pneumonia in a subject in need of such treatment. The methods comprise administering to a subject in need thereof, a pyrimidine of Formula I. ##STR1## wherein the variables are as defined in the specification.
Claims7
A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment, comprising administering to said subject a compound of Formula I:
- ##STR6## wherein:
- X and Y are located in the para or meta positions and are each ##STR7## wherein:
- each R.sub.1 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.1 groups together with --NCN-- to which they are attached form an imidazolinyl ring or tetrahydropyrimidinyl ring or two R.sub.1 groups together represent ##STR8## wherein m is from 1-3 and R.sub.7 is H or --CONHR.sub.8 NR.sub.9 R.sub.10, wherein R.sub.8 is loweralkyl, and R.sub.9 and R.sub.10 are each independently selected from the group consisting of H and lower alkyl;
- R.sub.2 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl;
- n is a number from 0 to 2;
- R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, loweralkoxy, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen;
- and
- R.sub.5 and R.sub.6 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl;
- or a pharmaceutically acceptable salt thereof, in an amount effective to treat Pneumocystis carinii pneumonia.
6 more elements
Dependencies are inferred from the claim text.