Back to results
US 5,686,440 AGranted
Aqueous 6-3-(3,4-dimethoxybenzyl)-amino-2-hydroxypropoxy! carbostyril composition
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsYuzo Kimura, Shinichi Ishikawa, Yoshito Masuda
Life of this patent
Estimating the term…
Abstract
This invention provides an aqueous composition wherein a hardly water-soluble active compound, 6-3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy!carbostyril or a salt thereof is dissolved in water in an effective amount, particularly in an amount sufficient for exhibiting the pharmacological activities, by using as a solubilizer DL-lactic acid.
Claims8
An aqueous pharmaceutical composition which comprises:
- (1) as an active ingredient, 6-3-(3,4-dimethoxybenzyl)amino-2-hydroxypropoxy!carbostyril or a salt thereof,
- (2) as a solubilizer, DL-lactic acid, and optionally
- (3) at least one pharmaceutically acceptable additive, wherein the 6-3-(3,4-dimethoxy-benzyl)amino-2-hydroxypropoxy!carbostyril or a salt thereof is present in an amount of 0.01 to 70% by weight based on the total weight of the composition, and the DL-lactic acid is present in an amount of 1 to 2000 parts by weight per 100 parts by weight of the 6-3-(3,4-dimethoxybenzyl)-amino-2-hydroxypropoxy!carbostyril or a salt thereof.
Dependencies are inferred from the claim text.