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AssigneeResearch Institute for Medicine and Chemistry Inc.
InventorsRobert Henry Hesse, Gaddam Subba Reddy, Sundara Katugam Srinivasasetty Setty
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The invention pertains to vitamin D amide derivatives of formula (I). These novel 1.alpha.-hydroxy vitamin D derivatives and their 20-epi analogues comprise compounds of formula (I) and corresponding 5,6-trans isomers, where Y represents an alkylene or alkenylene group containing up to four carbon atoms; R.sup.1 and R.sup.2 independently represent a hydrogen atom or a lower alkyl or cycloalkyl group, or R.sup.1 R.sup.2 N-- represents a heterocyclic group; and R.sup.3 and R.sup.4 independently represent a hydrogen atom or an O-protecting group. Active compounds, in which R.sup.3 and R.sup.4 are hydrogen atoms or metabolically labile O-protecting groups exhibit potent cell modulating effect, but minimal effect on calcium metabolism.
A method of treatment of a human or animal subject to combat neoplastic disease, bone disease, infection, autoimmune disease, host-graft reaction, transplant rejection, inflammatory disease, neoplasia, hyperplasia, acne, alopecia, psoriasis, skin aging, hypertension, rheumatoid arthritis or asthma, comprising administration to said subject of an effective amount of a compound of formula (I) or (II) ##STR6## where Y represents an alkylene or alkenylene group containing up to 4 carbon atoms;
Compounds of formula (I) or (II) ##STR7## where Y represents an alkylene or alkenylene group containing up to 4 carbon atoms;
Dependencies are inferred from the claim text.