2-oxoethyl derivatives as immunosuppressants

A compound having T-lymphocyte inhibitory activity and the generalized structure ##STR7## wherein n is 2 or 3;

• one of R.sup.2 and R.sup.3 is H, and the other is H or CH.sub.3 ;
• p is 0 or 1;
• and
• when p is 0, R.sup.4 is
• a) cyclohexyl optionally substituted by alkyl of 4-5 carbon atoms, or by phenyl, or by substituted phenyl wherein the substituent is halogen or methyl;
• b) bicycloheptyl optionally substituted up to three-fold by methyl;
• c) tricycloalkyl of 10 carbon atoms;
• d) 1,2,3,4-tetrahydronaphthyl;
• or
• e) methyl substituted by tricycloalkyl of 10 carbon atoms, which is in turn optionally substituted by methyl;
• when p is 1, R.sup.4 is
• f) butenyl substituted at least once by phenyl or by a diene of 11 carbon atoms;
• g) alpha-substituted benzyl wherein the alpha substituent is an alkyl group of 2-3 carbon atoms or cyclohexyl;
• or
• h) tricycloalkyl of 10 carbon atoms, substituted once by methyl;
• one of R.sup.11 and R.sup.12 is H, and the other is
• i) phenyl;
• or
• j) alkyl of 1-4 carbon atoms, optionally substituted by phenyl, or by benzyloxy, or by cyclohexyl;
• and
• R.sup.13 is unsubstituted benzyl, or benzyl substituted by methyl, or benzyl wherein the phenyl moiety is substituted by methoxy.