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US 5,686,295 AGranted
Process for the genetic manipulation of myxobacteria
AssigneeNovartis Finance Corporation
InventorsSamir Jaoua, Thomas Schupp, Snezana Neff
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AssigneeNovartis Finance Corporation
InventorsSamir Jaoua, Thomas Schupp, Snezana Neff
Estimating the term…
The present invention relates to a novel process for the genetic manipulation of myxobacteria, preferably of myxobacteria of the Sorangium/Polyangium group, which makes it possible for the first time specifically to apply recombinant DNA techniques to this group of organisms. The technical implementation of this process is based primarily on the preparation of recombinant DNA molecules which, by reason of their specific construction, are able to integrate genes or DNA sequences which code, where appropriate, for novel and desirable properties, with the aid of homologous recombination at sites, which are accurately defined by reason of the homologies present, within the bacterial genome, and on the insertion thereof into the myxobacterial cell.
A recombinant DNA molecule that integrates into the genome of Sorangium cellulosum, comprising:
A genetically modified Sorangium cellulosum cell comprising an exogenous DNA sequence integrated into its genome via homologous recombination.
Dependencies are inferred from the claim text.