Hepatocyte growth factor receptor antagonist antibodies and uses thereof
AssigneeGenentech, Inc.
InventorsRalph H. Schwall, Kelly Helen Tabor
Life of this patent
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Abstract
Hepatocyte growth factor (HGF) receptor antagonists are provided. The HGF receptor antagonists include HGF receptor antibodies and fragments thereof. The HGF receptor antagonists can be employed to block binding of HGF to HGF receptors or substantially inhibit HGF receptor activation. The HGF receptor antagonists may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer using the HGF receptor antagonists are also provided.
Claims14
A hepatocyte growth factor (HGF) receptor antagonist which is a monovalent antibody that specifically binds to a HGF receptor.
A hybridoma cell line which produces an antibody that when digested, yields a monovalent antibody which specifically binds to a HGF receptor and has HGF receptor antagonistic activity.
Dependencies are inferred from the claim text.