Detecting genetic predisposition to periodontal disease
OwnerKenneth S. Kornman, Gordon W. Duffinventors
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Abstract
A method and kit for the identification of a patient's genetic polymorphism pattern associated with increased periodontal disease severity is disclosed. The kit includes DNA sample collecting means and means for determining a genetic polymorphism pattern which is then compared to control samples to determine a patient's susceptibility to severe periodontal disease.
Claims9
A method of predicting a patient's susceptibility to increase periodontal disease severity, comprising the steps of:
- (a) isolating genomic DNA from a patient;
- (b) determining a genetic polymorphism pattern for IL-1A and IL-1B in the genomic DNA;
- and
- (c) comparing the genetic polymorphism patterns to a control sample, wherein said control sample comprises an IL-1A allele 2 plus an IL-1B (Taq 1) allele 2, and wherein the similarity of the genetic polymorphism pattern to the control sample indicates susceptibility to increased periodontal disease severity.
A method of predicting a patient's susceptibility to severe periodontal disease, said method comprising the steps of:
- a) isolating genomic DNA from a patient;
- and
- b) determining an allelic pattern for IL-1A and IL-1B in the genomic DNA;
- wherein the allelic pattern selected from the group consisting of
- at least one copy of IL-1A allele 2,
- at least one copy of IL-1B(TaqI) allele 2, and
- at least one copy of IL-1A allele 2 plus at least one copy of IL-1B(TaqI) allele 2
- indicates increased susceptibility to severe periodontal disease.
A kit for predicting a patient's susceptibility to severe periodontal disease, said kit comprising:
- (a) a DNA sample collecting means;
- (b) a means for determining a genetic polymorphism pattern for IL-1A and IL-1B, wherein said means comprises a set of polymerase chain reaction (PCR) primers, wherein said primers consist of:
- ##STR3## (c) a control sample comprising IL-1A allele 2 and IL-1B (Taq I) allele 2.
Dependencies are inferred from the claim text.