Hepatitis E virus peptides and methods
AssigneeGenelabs Technologies, Inc.
InventorsGregory R. Reyes, Albert W. Tam, Patrice O. Yarbough
Life of this patent
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Abstract
Peptide antigens are provided which are derived from the enterically transmitted non-A/non-B viral hepatitis agent, known as hepatitis E virus (HEV). The HEV derived peptides and in particular, SG3, are immunoreactive with sera from individuals infected with HEV. The antigens are useful as diagnostic reagents in diagnostic methods and kits for determining infection of an individual with HEV.
Claims12
A method of detecting hepatitis E virus (HEV) antibodies in an individual, comprising
- providing a peptide antigen having a sequence selected from the group consisting of SEQ ID NO:13 and SEQ ID NO:14, and internally consistent variations between SEQ ID NOS:13 and 14,
- reacting a serum sample taken from the individual with the peptide, and
- examining the peptide for the presence of bound antibodies, where the presence of bound antibodies indicates the presence of HEV antibodies in said individual.
A kit for ascertaining the presence of antibodies to hepatitis E virus in a serum sample taken from an individual, comprising
- a solid support with surface-bound peptide antigen having a sequence selected from the group consisting of SEQ ID NO:13 and SEQ ID NO:14, and internally consistent variations between SEQ ID NOS:13 and 14.
A method of detecting hepatitis E virus (HEV) antibodies in an individual, comprising
- providing a peptide antigen having a sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:12, and internally consistent variations between SEQ ID NOS:11 and 12,
- reacting a serum sample taken from the individual with the peptide, and
- examining the peptide for the presence of bound antibodies, where the presence of bound antibodies indicates the presence of HEV antibodies in said individual.
A kit for ascertaining the presence of antibodies to hepatitis E virus in a serum sample taken from an individual, comprising
- a solid support with surface-bound peptide antigen having a sequence selected from the group consisting of SEQ ID NO:11 and SEQ ID NO:12, and internally consistent variations between SEQ ID NOS:11 and 12.
Dependencies are inferred from the claim text.