Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsTully J. Speaker, Kenneth J. Sultzbaugh
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Abstract
An aqueous core microcapsule has a capsular wall provided with a peptide(s) of pre-determined binding specificity(ies) appended to the surface, the wall being the reaction product of an anionic polymer or salt thereof and a polyamine, salt thereof, mixtures thereof, or mixtures thereof with monoamines. The aqueous core may contain an active ingredient(s), and be targeted for delivery to specific cell tissues. The microcapsules are provided as a composition and in a kit with instructions for use in imaging, diagnosis, therapy, vaccination, and other applications.
Claims42
A composition, comprising at least one microcapsule(s) comprising an aqueous core surrounded by a capsular wall having a surface provided with peptide(s) linked thereto, the peptide(s) having a free segment(s) of pre-determined binding specificity(ies) capable of selective attachment to macromolecules, cells, and/or tissues displaying on their surfaces characteristic epitopic markers and the wall comprising the reaction product of a polymer having a plurality of anionic residues and a monomer having a plurality of amine residues wherein the capsular wall comprises an excess of either said anionic or amine residues, to which the peptide(s) is (are) linked.
Dependencies are inferred from the claim text.