US 5,686,110 A · Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance

Abstract

A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polyalkylene oxide polymer end capped with an alkyl or olefinic group which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.

Claims9

Dependent claims

A water-soluble complex comprising a substantially water-insoluble compound non-covalently bonded to a water-soluble, polymeric compound having the structure:

R--X--Z--X--R'
wherein:
R is a C.sub.6 --C.sub.30 alkyl, cycloalkyl, bicycloalkyl or olefin group;
X is independently selected from the group consisting of:
oxygen, sulfur, ##STR4## where L is selected from H or a C.sub.1-4 alkyl;
and Y is O or S;
Z is a polyalkylene oxide homopolymer or copolymer residue;
and
R' is a C.sub.1-24 alkyl;
said polymeric compound having a molecular weight of from about 1,000 to about 40,000.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application

08/459,057Filed 2 Jun 1995 · continuation in part

Priority

2 Jun 1994

Granted

11 Nov 1997

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C08G 65/329
Polymers modified by chemical after-treatment: with organic compounds
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
C08G
Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
A61K
Medicines and medical preparations

Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance

Life of this patent

Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance

Life of this patent

Abstract

Claims9