Prophylactic and therapeutic treatment of skin sensitization and irritation
AssigneeE.R. Squibb & Sons, Inc.
InventorsJohn J. Wille, Agis Kydonieus
Life of this patent
Estimating the term…
Abstract
Methods and devices for preventing and/or treating an adverse reaction of the skin to the presence of a skin-sensitizing and/or skin-irritating agent by administering an effective amount of a loop diuretic alone or in combination with at least one mast cell degranulator or at least one glucocorticosteroid.
Claims27
A method of preventing or treating an adverse reaction of the skin of a warm-blooded animal to the presence of at least one of a skin-sensitizing agent or a skin-irritating agent comprising topically administering to said warm-blooded animal an amount of an adverse skin reaction preventing or treating agent sufficient to prevent or treat said adverse reaction without achieving a systemically active concentration, said adverse skin reaction preventing or treating agent comprising at least one loop diuretic alone or in combination with at least one mast cell degranulator or glucocorticosteroid.
A transdermal delivery system for transdermally administering to a warm-blooded animal an amount of an adverse skin reaction preventing or treating agent sufficient to prevent or treat said adverse reaction without achieving a systemically active concentration, said adverse skin reaction preventing or treating agent comprising a loop diuretic alone or in combination with at least one mast cell degranulator or at least one glucocorticosteroid, said system comprising:
- (a) a first transdermal device comprising a matrix for placing the adverse skin reaction preventing or treating agent in transmitting relationship to the skin;
- and
- (b) a second transdermal device comprising a matrix for placing a therapeutic agent in transmitting relationship to the skin after the adverse skin reaction preventing or treating agent has been transdermally administered to the skin from the first transdermal device.
A method of transdermally administering to a warm-blooded animal a therapeutic agent without thereby eliciting an adverse reaction from the skin comprising transdermally administering before, after or during the administration of the therapeutic agent an amount of an adverse skin reaction preventing agent sufficient to prevent said adverse reaction without achieving a systemically active concentration, said adverse skin reaction preventing agent comprising a loop diuretic alone or in combination with at least one mast cell degranulator or at least one glucocorticosteroid to said warm-blooded animal.
Dependencies are inferred from the claim text.