Active substance patch for the release of estradiol to the skin
AssigneeLTS Lohmann Therapie-Systeme AG
InventorTeresa Marie Murphy
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Abstract
An active substance patch releasing estradiol to the skin is characterized by the fact that it consists essentially of a backing layer and an attached active substance reservoir which comprises pressure sensitive adhesive and in which the active substance is at least partially soluble, and of a removable protective layer covering the adhesive film, the active substance reservoir being a polymer matrix which--in order to improve the bioavailability of the estradiol--comprises an added penetration enhancer of the general formula: ##STR1## wherein R=--CH.sub.2 OH or --CH.sub.2 --O--CH.sub.2 --CHOH--CH.sub.2 OH.
Claims8
An active substance patch for the release of estradiol to the skin consisting essentially of a backing layer and an active substance reservoir connected thereto which comprises estradiol and a pressure sensitive adhesive and in which the estradiol is at least partially soluble, and a removable protective layer covering the adhesive film, wherein the active substance reservoir is a polymer matrix to which, in order to improve the bioavailability of the estradiol, a penetration enhancer of the formula ##STR3## is added, wherein R=--CH.sub.2 OH or --CH.sub.2 --O--CH.sub.2 --CHOH--CH.sub.2 OH,
- the weight ratio of estradiol to penetration enhancer being 1:3 to 1:15.
Dependencies are inferred from the claim text.