Cosmetic or pharmaceutical composition containing a combination of a polyphenol and a ginkgo extract
AssigneeL'oreal
InventorQuang-Lan N'Guyen
Life of this patent
Estimating the term…
Abstract
A cosmetic or pharmaceutical composition containing a synergistically active oxidation inhibiting system consisting of a combination of a ginkgo extract and at least one polyphenol compound. For example, the ginkgo extract may be a hexane extract of ginkgo leaves and the polyphenol compound may be a flavonoid. Said composition may be used to prevent and treat cell damage on the skin, scalp or mucosae by free radicals induced especially by atmospheric pollutants and/or ultraviolet radiation, and/or for controlling the phenomenon of accelerated skin ageing.
Claims14
A cosmetic or pharmaceutical composition comprising an antioxidizing system consisting of the combination of a ginkgo extract and at least one polyphenol compound, said ginkgo extract being obtained by extraction of ginkgo leaves with a nonpolar solvent;
- wherein said polyphenol compound is selected from the group consisting of a flavonoid, carnosic acid, carnosol, a 2,5-dihydroxy benzoic acid, a compound of formula (III) ##STR9## wherein R.sub.1 " represents --O--Alk, OH or --N(r')(r") wherein Alk represents linear or branched C.sub.1 -C.sub.20 alkyl;
- linear or branched C.sub.1 -C.sub.20 alkyl substituted by one or more hydroxyl groups;
- linear or branched C.sub.1 -C.sub.20 alkyl substituted by one or more alkoxy groups, or Alk representing C.sub.2 -C.sub.20 alkenyl;
- r' and r", each independently represent H, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.6 hydroxyalkyl or C.sub.3 -C.sub.6 polyhydroxyalkyl;
- r represents a number, including zero, so that said --(CH.sub.2).sub.r --COR.sub.1 " contains at most 21 carbon atoms;
- and
- R.sub.2 " and R.sub.3 ", each independently, represent H or C.sub.1 -C.sub.4 alkyl, or R.sub.2 " represents C.sub.1 -C.sub.4 alkoxy, a C.sub.1 -C.sub.8 alkyl ester or caffeic acid, a phytol ester of caffeic acid, a caffeic acid amide of formula (V) ##STR10## wherein Z' represents C.sub.1 -C.sub.8 alkyl, and tannic acid;
- said flavonoids being selected from the group consisting of taxifolin, catechin, epicatechin, eriodictyol, naringenin, rutin, troxerutin, chrysin, tangeretin, luteolin, epigallocatechin, epigallocatechin gallate, quercetin, fisetin, kaempferol, galangin, gallocatechin and epicatechin gallate.
A cosmetic or pharmaceutical composition comprising an antioxidizing system consisting of the combination of a ginkgo extract and at least one polyphenol compound, said ginkgo extract being obtained by extraction of ginkgo leaves with a nonpolar solvent, wherein said polyphenol is selected from the group consisting of a flavonoid, carnosic acid, carnosol, a 2,5-dihydroxybenzoic acid, a compound of formula (III) ##STR11## wherein R.sub.1 " represents --O--Alk, OH or --N(r')(r") wherein Alk represents linear or branched C.sub.1 -C.sub.20 alkyl;
- linear or branched C.sub.1 -C.sub.20 alkyl substituted by one or more hydroxy groups;
- linear or branched C.sub.1 -C.sub.20 alkyl substituted by one or more alkoxy groups, or Alk representing C.sub.2 -C.sub.20 alkenyl;
- r' and r", each independently represents H, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.6 hydroxyalkyl or C.sub.3 -C.sub.6 polyhydroxyalkyl;
- r represents a number, including zero, so that said --(CH.sub.2).sub.r --COR.sub.1 " contains at most 21 carbon atoms;
- and
- R.sub.2 " and R.sub.3 ", each independently, represents H or C.sub.1 -C.sub.4 alkyl, or R.sub.2 " represents C.sub.1 -C.sub.4 alkoxy, a C.sub.1 -C.sub.8 alkyl ester or caffeic acid, a phytol ester or caffeic acid, a caffeic acid amide of formula (V) ##STR12## wherein Z' represents C.sub.1 -C.sub.8 alkyl, and tannic acid, wherein said flavonoids are selected from the group consisting of compounds of formula (I) and formula (II) ##STR13## wherein A", B", C" and D", independently of one another, represent H or OH;
- E" represents H, OH or OX', where X' represents ##STR14## F", G" and J" represent, independently of one another, H or OH;
- and X.sub.1 represents --CH.sub.2 --, --CO-- or --CHOH--;
- A', C' and D', independently of one another, represent H, OH or OCH.sub.3 ;
- E' represents H, OH or OR', where R' represents a residue of rutinose;
- and
- B', F', G' and J', independently of one another, represent H, OH, OCH.sub.3 or --OCH.sub.2 --CH.sub.2 --OH.
Dependencies are inferred from the claim text.