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US 5,686,079 AGranted
Oral immunization by transgenic plants
AssigneeWashington University
InventorsRoy Curtiss, III, Guy A. Cardineau
Life of this patent
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Abstract
The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.
Claims12
A method for eliciting a secretory immune response in a human or other animal which comprises:
- orally administering an effective amount of a composition which comprises a transgenic plant or tissue from a transgenic plant, said transgenic plant or plant tissue contains and is capable of expressing a DNA sequence coding an antigen of a pathogenic microorganism,
- said antigen selected from the group consisting of:
- i) a colonization antigen,
- ii) a virulence antigen,
- iii) an antigenic determinant of either antigen, or
- iv) a fusion protein comprising either antigen and an antigenic determinant thereof,
- said antigen or antigenic determinant thereof being capable of eliciting said secretory immune response.
4 more elements
Dependencies are inferred from the claim text.