gD-negative bovine herpesvirus mutant, capable of direct cell-to-cell transmission
AssigneeAkzo Nobel N.V.
InventorGunther Keil
Life of this patent
Estimating the term…
Abstract
The present invention relates to a gD-negative Bovine Herpesvirus mutant, that has the property of direct cell-to-cell transmission. The invention also relates to a DNA-fragment capable of conferring this property to Bovine Herpesviruses, not possessing the direct cell-to-cell transmission capability. Also, the invention relates to a vaccine based on this mutant, and a method for the protection of animals against Bovine Herpesvirus.
Claims10
A Bovine Herpesvirus (BHV) mutant that is gD-negative and contains a mutated gH gene, wherein said BHV mutant is capable of direct cell-to-cell transmission, and wherein said mutated gH gene is present in an 6.5 kbp HindIII-BglII restriction fragment, or a subfragment thereof, said fragment being obtainable from the E. coli deposited with the CNCM under accession No. I-1446.
An 8.5 kbp HindIII-BglII restriction fragment, said fragment being isolatable from E. coli transformed with DNA comprising said fragment, and deposited with the Collection Nationale de Cultures de Micro-organismes (CNCM) of the Institut Pasteur at Paris France under nr. I-1446.
Dependencies are inferred from the claim text.