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US 5,686,071 AGranted
Polymer affinity system for the delivery of cytotoxic material and other compounds to sites of disease
AssigneePer Immune Holdings, Inc.
InventorsRamaswamy Subramanian, Fang Shi
Life of this patent
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Abstract
The use of interacting polymers and oligomers to selectively target compounds to desired sites, in-vitro and in-vivo, wherein the first polymer or oligomer is bound to a targeting agent and the second polymer or oligomer is bound to an active agent, such as a drug, a metal or a radioisotope.
Claims3
A method for targeting active agents to target sites, comprising
- providing two polymers that have binding affinity for each other,
- coupling a targeting agent to the first of the polymers to form a targeting agent-polymer conjugate,
- coupling an active agent to the second of the polymers in the pair to form an active agent-polymer complex,
- administering the targeting agent-polymer conjugate to a subject,
- permitting the conjugate to localize to a target tissue for which the targeting agent has affinity,
- administering the active agent-polymer complex to the subject, and
- permitting the complex to bind to the localized targeting-agent polymer conjugate, whereby the active agent becomes localized to the target tissue,
- wherein the targeting agent is an antibody or an antigen binding fragment having binding specificity for a tumor associated antigen and retaining that specificity in the targeting agent-polymer conjugate, wherein the active agent is selected from the group consisting of a radiometal, a radiohalogen, a metal with magnetic properties and fluorescent metal, and wherein the polymers are selected from the group consisting of poly (N-vinyl pyrrolidone), poly (ethyleneminine) and ply (acrylic acid).
5 more elements
Dependencies are inferred from the claim text.