Back to results
US 5,686,070 AGranted
Methods for treating bacterial pneumonia
AssigneesGenentech, Inc., Indiana University
InventorsClaire M. Doerschuk, Sherman Fong, Caroline Alice Hebert, Kyung Jin Kim, Steven R. Leong
Life of this patent
Estimating the term…
Abstract
Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias.
Claims5
A method of treating bacterial pneumonia in a mammal comprising administering to the mammal a therapeutically effective amount of an anti-IL-8 monoclonal antibody having the following characteristics:
- ability to bind human IL-8 with a Kd between about 1.times.10.sup.-8 to about 1.times.10.sup.-11 M, ability to inhibit neutrophil chemotaxis in response to IL-8, and ability to inhibit IL-8 mediated elastase release by neutrophils;
- wherein the monoclonal antibody does not bind to C5a, .beta.-TG or platelet factor 4.
Dependencies are inferred from the claim text.