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US 5,686,068 AGranted
Isolated peptides derived from MAGE-2, cytolytic T cells specific to complexes of peptide and HLA-A2 molecules, and uses thereof
AssigneesLudwig Institute for Cancer Research, Leiden University
InventorsCornelius J. M. Melief, M. W. Visseren, Sjoerd van der Burg, Pierre van der Bruggen, Thierry Boon-Falleur
Life of this patent
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Abstract
New peptides derived from the MAGE-2 molecule and which bind to HLA-A*0201 molecules are disclosed. Some of these are especially useful because, when complexed to their HLA-A*0201 partner molecules, they induce CTL proliferation.
Claims7
Isolated cytolytic T cell clone specific for a complex of an HLA-A2 molecule and one of:
- SEQ ID NO:
- 3, SEQ ID NO:
- 5, and SEQ ID NO:
- 9.
1 more element
Method for inducing production of cytolytic T cells in a subject, comprising administering an amount of at least one of SEQ ID NO:
- 3, SEQ ID NO:
- 2, and SEQ ID NO:
- 9, to a subject who presents HLA-A2 molecule on cells, in an amount sufficient to provoke cytolytic T cell proliferation to complexes of HLA-A2 and one of SEQ ID NO:
- 3, SEQ ID NO:
- 5, and SEQ ID NO:
- 9.
3 more elements
Isolated peptide selected from the group consisting of:
- SEQ ID NO:
- 67, SEQ ID NO:
- 68, and SEQ ID NO:
- 69.
1 more element
Dependencies are inferred from the claim text.