US 5,686,065 A · Topical siloxane sunscreen compositions having enhanced performance and safety

Abstract

Methods and compositions that provide for the long-term adhesion and slow-release of various bioactive agents on the surface of human skin utilize siloxane bridging agents activated for reaction with the skin surface which bind the bioactive agent to the skin surface. Since the topical agent remains bound to the continuously renewing epidermis, safety is enhanced for many bioactive agents. Slight modifications of the siloxane bridging compounds or bioactive agents allows for more or less adhesion to the skin, controlling the degree of release of the agent. Skin treatments according to the invention can provide enhanced repellency to microorganisms, insect bites, sun, water, poison ivy/oak, and other skin irritants, and other effects such as artificial skin coloring and administration of topical drugs, among others.

Claims34

Dependent claims

A method for adhering a sunscreen to a body surface, which comprises:

applying to the body surface a first component containing an oxysilane in anhydrous form, wherein the oxysilane has the formula:
Si(R.sup.2).sub.n (OR.sup.4).sub.p (IIIa)
or an oligomer or polymer thereof, wherein p is 2 or 3 and n is 1 or 2, the sum of n+p being 4, R.sup.2 is a substituted or unsubstituted C.sub.1 -C.sub.20 alkyl, aryl or aralkyl group;
R.sup.4 is H, a substituted or unsubstituted C.sub.1 -C.sub.20 alkyl, aryl or aralkyl group, or a monovalent metal M selected from sodium and potassium, provided that R.sup.4 OH is substantially non-toxic;
and
applying to the body surface a second component stored separately from the first component, which second component contains the sunscreen, at or near the same time as the first component is applied, so that the first and second components mix together and undergo a coupling reaction on the body surface, wherein the second component contains a reactive sunscreen having the formula:
R.sup.1 OH (IIIb)
wherein R.sup.1 represents a sunscreen group that remains active as a sunscreen following the coupling reaction between the --OH group of (IIIb) and a group R.sup.4 of (IIIa) to couple (IIIa) and (IIIb) and form R.sup.4 OH as a byproduct.

5 more elements

Dependencies are inferred from the claim text.

Topical siloxane sunscreen compositions having enhanced performance and safety

Life of this patent

Topical siloxane sunscreen compositions having enhanced performance and safety

Life of this patent

Abstract

Claims34