Galvanically active transdermal therapeutic system

A process for producing a packaged transdermal therapeutic system for transdermal iontophoretic therapies with a therapeutic system for carrying out transdermal iontophoretic therapies with a flexible, laminated structure, comprising a package impermeable to water vapor and containing a laminated structure comprising a backing layer (1) which is impermeable to active substances as well as two sheet-like galvanic elements (3,4) having skin-facing electrodes, positioned separately from each other and connected in series via an electrically conductive connecting layer (2), which galvanic elements are positioned in reversed arrangement of anode and cathode the same distance from a surface of the backing layer (1), the galvanic elements (3,4) comprising a multi-layer structure, the thickness of the individual layers ranging from 1 to 500 .mu.m, the skin-facing electrodes of said galvanic elements having ionically conductive layers (6,7) thereon made of a material which absorbs moisture and, after absorption of moisture becomes ionically conductive, the basic material of the electrodes and any electrically conductive layers comprising at least one of polymers and copolymers of vinyl acetate or acrylic acid and esters thereof, polyurethane and polyisobutylene, an ionically conductive layer on at least one of the skin-facing electrodes containing a pharmaceutically active substance, any chemicals in any layer, being in thermally dried condition, wherein said process comprises forming the galvanic elements layer by layer by either dissolution or suspension in a solvent, spreading each as a thin layer, drying, and subsequently laminating the three layers on top of each other, the electrodes being spread, extruded, or rolled-out in a hot-melt-process using a thermoplastic polymeric mixture, an electrolytic layer on the galvanic elements being obtained by impregnating a paper, non-woven, or porous foil with the solution of an electrolyte, drying the laminated layered structure thereby almost completely removing any water, and sealing the laminated layered structure in a water vapor-impermeable package.