Mammalian model of a malignant disorder
AssigneeSeragen, Inc.
InventorsSerene E. Forte, Patricia Bacha
Life of this patent
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Abstract
A method for producing a mouse having a systemic malignant disease which mimics a human IL-2 expressing. T-cell malignancy, which includes administering to a mouse a mixture of passaged cells comprising cancer causing cells, the mixture having been rendered cancer causing by in vivo passage of tumor inducing cells in athymic mice.
Claims11
A method of producing a mouse having a systemic malignancy of the lymphatic tissue, said method comprising administering to a mouse with a non-compromised immune system a mixture of passaged cells comprising cells capable of causing a systemic malignancy of the lymphatic tissue in a non-immunocompromised mouse, said mixture of passaged cells being generated by the in vivo passage of CTLL-transformant derived cells in athymic mice.
A composition comprising CP3 cells (ATCC No. CRLL 10574), said cells being capable of causing a systemic malignancy of the lymphatic tissue in a non-immunocompromised mouse.
Dependencies are inferred from the claim text.