Misoprostol
AssigneeTorcan Chemical Ltd.
InventorsYee-Fung Lu, Raymond So, Dan To, Casimir G. Antczak
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Abstract
In a process for making synthetic prostaglandin-type compounds such as misoprostol, organo metallic cuprate complexes capable of reacting with cyclopentenones are prepared by reaction of an alkyl lithium compound with a cuprous halide, followed by reaction of the resulting complex with a vinyl stannane, using an excess of alkyl lithium in the initial reaction and maintaining the excess present during the formation of the organo metallic cuprate complex.
Claims10
A process for preparing an organometallic cuprate complex carrying an organic unsaturated ligand, said cuprate complex being capable of reaction with an enone to effect addition of the organic unsaturated ligand from the cuprate complex onto the enone, which comprises reacting in excess of two equivalents of lower alkyl lithium with one equivalent of a cuprous halide, and reacting the product thereof with a vinyl stannane compound of the general formula:
- ##STR9## in which each of R, R.sub.1, and R.sub.2 is an independently selected lower alkyl group and Y is an optionally substituted vinyl group.
Dependencies are inferred from the claim text.