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US 5,684,175 AGranted
C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
AssigneesNaPro BioTherapeutics, Inc., Bryn Mawr College
InventorsNicholas J. Sisti, Charles S. Swindell, Madhavi C. Chander
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Abstract
The synthesis of paclitaxel obtained from the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side chain acid, thereby producing an intermediate which may be acylated and deprotected to produce paclitaxel.
Claims5
A chemical compound having the formula:
- ##STR30## wherein P.sub.1 is a hydrogenatable benzyl protecting group;
- and R.sub.1 is an olefinic or aromatic group or PhCH.sub.2.
A chemical compound having the formula:
- ##STR31## wherein P.sub.1 is a hydrogenatable benzyl protecting group and R.sub.1 is PhCH.sub.2.
Dependencies are inferred from the claim text.