Process for the preparation and isolation of atracurium besylate
AssigneeAbbott Laboratories
InventorsSteven A. Chamberlin, Ashok V. Bhatia, Deborah A. Davis, Keith A. Drengler
Life of this patent
Estimating the term…
Abstract
A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N, N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracuriurn besylate is precipitated.
Claims27
A process of making, 2,2'-1,5-pentanediylbis-oxy(3-oxo-3,1 -propanediyl)!!bis1-3,4-dimethoxyphenyl)-methyl !-1,2,3,4-tetrahydo-6,7-dimethoxy-2-methlisoquinolinium! dibenzenesulfonate, comprising the steps of:
- (a) combining N, N'-4,10-dioxa-3,11 -dioxotridecylene-1,13-bis-tetrahydro-papaverine, methyl benzenesulfonate and a catalytic amount of an insoluble base to form a reaction mixture and
- b) precipitating, 2,2'-1,5-pentanediylbis-oxy(3-oxo-3,1-propanediyl)!!bis1-3,4-dimethoxy phenyl)-methyl!-1,2,3,4-tetrahydo-6,7-dimethoxy-2-methylisoquinolinium! dibenzenesulfonate.
Dependencies are inferred from the claim text.