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AssigneeErziehungsdirektion of the Canton Zurich
InventorsMartin E. Schwab, Pierenrico W. Caroni
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The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuroblastoma cells, and can also inhibit fibroblast spreading. Such inhibitory proteins include a 35,000 dalton and a 250,000 dalton molecular weight protein and analogs, derivatives, and fragments thereof. The CNS myelin associated inhibitory proteins may be used in the treatment of malignant tumors. The present invention is also directed to antibodies to the CNS myelin associated proteins; such antibodies can be used in the diagnosis and therapies of nerve damage resulting from trauma, infarction, and degenerative disorders of the central nervous system. In a specific embodiment of the invention, monoclonal antibody IN-1 may be used to promote regeneration of nerve fibers over long distances in spinal cord lesions.
An essentially purified and isolated neurite growth inhibitory factor consisting of a protein characterized by the following properties:
An essentially purified and isolated neurite growth inhibitory factor consisting of a protein characterized by the following properties:
An essentially purified and isolated neurite growth inhibitory factor consisting of a protein characterized by the following properties:
Monoclonal antibody IN-1, as produced by cell line IN-1, as deposited with the ECACC and assigned accession number 88102801.
Monoclonal antibody IN-2, as produced by cell line IN-2, as deposited with the ECACC and assigned accession number 88102802.
Dependencies are inferred from the claim text.