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US 5,684,121 AGranted
N-vinyl lactam polymer containing tablets of low friability and high rate of dissolution
AssigneeISP Investments Inc.
InventorKolazi S. Narayanan
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Abstract
This invention relates to a coprecipitated binder composition used for the compression of pharmaceutically and agriculturally active components to provide a non-friable, readily soluble or dispersible pill or tablet. The invention also relates to the process for preparing the binder and to its incorporation in a formulation with the active ingredient.
Claims8
The process of forming a binder for a bioactive chemical to produce an attrition resistant bioactive tablet having a dispersion rate less than 100 inversions/500 mg which comprises:
- (a) forming a mixture of an N-vinyl lactam polymer and a polybasic carboxylic acid in a mutual solvent at a mole ratio of from about 1:0.1 to about 1:10 based on polymer to carboxyl group,
- (b) coprecipitating said polymer and carboxylic acid at a temperature of from about 35.degree. to 60.degree. C. for a period of from about 2 to about 8 hours to form a complex,
- (c) drying to solid form said coprecipitate at a temperature below 60.degree. C. by vacuum distillation or by freeze drying to remove solvent and
- (d) grinding said solids to an average particle diameter of from about 20 to about 350 microns.
1 more element
Dependencies are inferred from the claim text.