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US 5,684,050 AGranted
Stable emulsions of highly fluorinated organic compounds
AssigneeHemaGen/PFC
InventorsLeland C. Clark, Jr., Robert Francis Shaw
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Abstract
Stable emulsions of highly fluorinated organic compounds for use as oxygen transport agents, "artificial bloods" or red blood cell substitutes and as contrast agents for biological imaging. The emulsions comprise a highly fluorinated organic compound, an oil that is not substantially surface active and not significantly soluble in water, a surfactant and water.
Claims26
A physiologically acceptable emulsion comprising a highly fluorinated organic compound;
- an oil that is not substantially surface active and not significantly water soluble;
- a surfactant and water, wherein
- (a) the highly fluorinated compound is present in the emulsion in an amount between about 15 and 70% by volume;
- (b) the oil is present in an amount between about 10 and 30% by weight of the volume of the emulsion excluding the volume of the highly fluorinated organic compound;
- and
- (c) the emulsion is stable after heating to at least 115.degree. C. for about 15 minutes.
3 more elements
A physiologically acceptable emulsion comprising
- (a) a highly fluorinated organic compound in an amount between about 15 and 70% by volume;
- (b) an oil that is not substantially surface active and not significantly water soluble in an amount between about 10 and 30% by weight of the non-highly fluorinated organic compound volume;
- (c) a surfactant in an amount between about 0.5 and 7% by weight of the non-highly fluorinated organic compound volume;
- and
- (d) water, wherein the emulsion is stable after heating to at least 115.degree. C. for about 15 minutes.
2 more elements
Dependencies are inferred from the claim text.