Cytotoxic macrolides and methods of use
AssigneeHarbor Branch Oceanographic Institution, Inc.
InventorsPaul A. Horton, Frank Koehn, Ross E. Longley, Oliver J. McConnell, Shirley A. Pomponi
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Abstract
Novel macrolide compounds, including Lasonolide A and Lasonolide B, have been isolated from a marine sponge. These compounds, analogs, derivatives, or isomers of these compounds, and compositions comprising the compounds or its derivatives, are useful as antitumor agents and as biochemical tools.
Claims15
A purified macrolide compound selected from the group consisting of Compound (I), Compound (II), Compound (III), Compound (IV), Compound (V), Compound (VI), Compound (VII), Compound (VIII), Compound (IX), or an analog, derivative, or salt thereof.
A pharmaceutical composition for the inhibition of cancer cell growth, said composition comprising an appropriate pharmaceutical carrier and a macrolide compound or an analog, derivative, or salt thereof, wherein said macrolide compound is selected from the group consisting of Compound (I), Compound (II), Compound (III), Compound (IV), Compound (V), Compound (VI), Compound (VI), Compound (VIII), and Compound (IX).
A method for treating a human or animal hosting cancer cells, said method comprising administering to said human or animal a cancer cell inhibiting amount of a macrolide compound or an analog, derivative, or salt thereof, wherein said macrolide compound is selected from the group consisting of Compound (I), Compound (II), Compound (III), Compound (IV), Compound (V), Compound (VI), Compound (VII), Compound (VIII), and Compound (IX).
Dependencies are inferred from the claim text.