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US 5,684,030 AGranted
2-substituted benzimidazole derivatives
AssigneeAmerican Home Products Corporation
InventorsHassan M. Elokdah, Sie-Yearl Chai, Theodore S. Sulkowski
Life of this patent
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Abstract
Disclosed herein are compounds of the formula: ##STR1## where R.sub.1 is substituted phenyl in which the substituents are one or two halogens, alkyl groups, carboxyl groups or alkoxycarbonyl groups; R.sub.2 is H or alkyl; R.sub.3 and R.sub.4 are, independently, H, alkyl, halogen or nitro; and n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.
Claims7
A pharmaceutical composition comprising a compound of the formula:
- ##STR6## where R.sub.1 is substituted phenyl in which the substituents are one or two halogens, carboxyl groups or alkoxycarbonyl groups of 2 to 7 carbon atoms each;
- R.sub.2 is H or alkyl of 1 to 6 carbon atoms;
- R.sub.3 and R.sub.4 are, independently, H, alkyl of 1 to 6 carbon atoms, halogen or nitro;
- and n is 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
2 more elements
A compound of the formula:
- ##STR7## where R.sub.1 is substituted phenyl in which the substituents are one or two halogens, carboxyl groups or alkoxycarbonyl groups of 2 to 7 carbon atoms each;
- R.sub.2 is H or alkyl of 1 to 6 carbon atoms;
- R.sub.3 and R.sub.4 are, independently, H, alkyl of 1 to 6 carbon atoms, halogen or nitro;
- and n is 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.