Sulphorous derivatives of imidazole, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions
AssigneeRoussel Uclaf
InventorsJean Claude Caille, Alain Corbier, Michel Fortin, Gilles Hamon, Simone Jouquey, Jean Paul Vevert
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Abstract
Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin II in warm-blooded animals.
Claims6
A compound selected from the group consisting of a compound of the formula ##STR128## wherein R.sub.1 is alkyl of 1 to 13 carbon atoms, R.sub.26 is --S--(O).sub.n --alkyl or --S(O).sub.n --phenyl, the alkyl and phenyl being optionally substituted with a member of the group consisting of --OH, alkyl, halogen, haloalkoxy, haloalkyl, alkylthio, alkoxy, alkenyl and alkynyl of up to 6 carbon atoms, phenoxy, phenylalkoxy, carbamoyl, acyl and acyloxy of an C.sub.1 -C.sub.6 -hydrocarbon organic carboxylic acid, free, salified or C.sub.1 -C.sub.4 alkyl esterified carboxy, tetrazolyl, --CN, --NO.sub.2 and mono and dialkylamino of 1 to 6 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of --OH, alkyl and alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, free, salified or C.sub.1 -C.sub.4 alkyl esterified carboxy and tetrazolyl, n is 0, 1 or 2, R.sub.3b is selected from the group consisting of --COOC.sub.2 H.sub.5, --CH.sub.2 --O--C(CH.sub.3).sub.2 --O--CH.sub.3 and --COO--CH.sub.2 --OOC--C(CH.sub.3).sub.3, R.sup.1 is selected from the group consisting of --COOH and tetrazolyl, and their non-toxic, pharmaceutically acceptable salts with acids and bases thereof.
Dependencies are inferred from the claim text.