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US 5,684,024 AGranted
Pyrazole dimers compositions and methods for treating influenza
AssigneeViroPharma Incorporated
InventorsGuy D. Diana, Dorothy C. Young, Tandy D. Goldstein, Theodore J. Nitz, John Swestock, William P. Gorczyca
Life of this patent
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Abstract
Substituted pyrazole dimers are useful in prophylaxis and treatment of influenza virus infections.
Claims25
A compound having the formula:
- ##STR26## wherein R.sub.1 represents a substituent selected from the group consisting of R'CO, COOH, COOR", CONH.sub.2, SO.sub.2 NH.sub.2 and halogen;
- V represents a substituent selected from the group consisting of COOH, CONH.sub.2, COOR"', SO.sub.2 NH.sub.2, ##STR27## W, X, Y and Z represent the same or different substituents selected from the group consisting of H, alkyl (C.sub.1 -C.sub.6), halogen, CF.sub.3, O-alkyl (C.sub.1 -C.sub.6), COOH, CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, COOR"" and CONH.sub.2 ;
- R', R", R"' and R"" represent the same or different alkyl (C.sub.1 -C.sub.6) substituents, tautomeric forms of said compound, and the pharmaceutically acceptable salts of said compound.
A compound having the formula ##STR28## wherein R.sub.1 represents CH.sub.3 CO;
- V represents a substituent selected from the group consisting of COOH, COOR, and CONH.sub.2 ;
- W, X, Y and Z represent substituents selected from the group consisting of H, CH.sub.3, OCH.sub.3, COOH, COOR', CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, CONH.sub.2, and Cl, R and R' being the same or different lower alkyl group;
- tautomeric forms of said compound;
- and the pharmaceutically acceptable salts of said compound.
1 more element
Dependencies are inferred from the claim text.