Method of treating cardiac insufficiency
AssigneeHoechst Aktiengesellschaft
InventorsRainer Henning, Hansjorg Urbach, Volker Teetz, Rolf Geiger, Bernward Scholkens
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Abstract
The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
Claims6
A method of treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of an angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor having the formula Ia ##STR6## in which R.sup.2 and R.sup.3 are identical or different and are selected from hydrogen, (C.sub.1 -C.sub.6)-alkyl and (C.sub.6 -C.sub.12)-aryl-(C.sub.1 -C.sub.4)-alkyl or a pharmaceutically acceptable salt thereof.
A method of treating cardiac insufficiency in a mammal comprising the step of administering to a mammal in recognized need of, and for the purpose of said treatment, an amount of an angiotensin-converting enzyme inhibitor effective for said treatment, said angiotensin-converting enzyme inhibitor being N-(1-S-carbethoxy-3-phenyl-propyl)-S-alanyl-S-1,2,3,4-tetrahydroisoquinoli ne-3-carboxylic acid or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.