Imidazopyridines as pharmaceutical agents
AssigneeMerck Patent GmbH
InventorsWerner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
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Abstract
Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
Claims11
An imidazopyridine compound of the formula I ##STR5## wherein R is ##STR6## R.sup.1 is F, R.sup.2 is --SO.sub.2 NH--COR.sup.5,
- R.sup.3 is A,
- R.sup.4 C.sub.n H.sub.2n --CO--NR.sup.6 R.sup.7,
- R.sup.5 is A, --C.sub.t --C.sub.2t -(C.sub.3 -C.sub.8 -cycloalkyl), C.sub.t H.sub.2t --Ar, --OA, --O--C.sub.t H.sub.2t -(C.sub.3 -C.sub.8 -cycloalkyl), --O--C.sub.t H.sub.2t --Ar, --C.sub.p H.sub.2p --(O-C.sub.3 -C.sub.8 -cycloalkyl) or --C.sub.p H.sub.2p --O--Ar,
- R.sup.6 and R.sup.7 are each H, A, or ArC.sub.n H.sub.2n,
- R.sup.6 and R.sup.7 together are also an alkylene chain having 2-5 atoms,
- A is C.sub.1 -C.sub.6 -alkyl,
- Ar is an unsubstituted phenyl group,
- t is 0, 1, 2 or 3,
- n is 1, 2, 3, 4 or 5, and
- p is 1 or 2,
- or a salt thereof.
Dependencies are inferred from the claim text.