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US 5,684,009 AGranted
Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides
AssigneeAcademic Pharmaceuticals, Inc.
InventorVasant Ranade
Life of this patent
Estimating the term…
Abstract
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides in Bis-Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed are methods for preparing such solutions.
Claims4
A solution suitable for parenteral administration comprising about 1.0 to 2.0 mg/ml of a compound of the formula ##STR2## wherein X is halogen;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4 are independently selected from hydrogen and alkyl having from 1 to 6 carbon atoms;
- and
- R.sub.5 is hydrogen or alkyl having from 1 to 6 carbon atoms, dissolved in an aqueous about 0.05M Bis-Tris buffer system having a pH of from about 11.5 to 12.0.
A solution comprising an effective diuretic amount of a mixture of furosemide and about 1.0 to 2.0 mg/ml metolazone in an aqueous about 0.05M Bis-Tris buffer at a pH of from about 11.5 to 12.
Dependencies are inferred from the claim text.