Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsJeffrey S. Borer, Steven M. Goldfine
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Abstract
Methods are disclosed for inhibiting cardiac fibroblast growth, and for inhibiting cardiac fibrosis, wherein said methods use, as the active agent, a carbostyril derivative.
Claims5
A method for inhibiting cardiac fibroblast growth comprising contacting cardiac fibroblasts with an effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR3## wherein R is a benzoyl group which may optionally have lower alkoxygroups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
A method for inhibiting cardiac fibrosis in a subject in need of such treatment, comprising administering to said subject a pharmaceutically effective amount of a carbostyril derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof:
- ##STR4## wherein R is a benzoyl group which may optionally have lower alkoxy groups on the phenyl ring as substituents and the carbon-carbon bond in the 3 and 4 positions of the carbostyril skeleton is a single bond or double bond.
Dependencies are inferred from the claim text.