Tricyclic triazolo derivatives, processes for producing the same and the uses of the same

A tricyclic triazolo derivative of the formula (I):

• ##STR190## wherein R.sup.1 represents hydrogen, lower alkyl or C.sub.3 -C.sub.5 cycloalkyl;
• R.sup.2 and R.sup.3 each independently represent hydrogen, lower alkyl, lower alkoxy or halogen;
• W represents C.dbd.O or CR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 each independently represent hydrogen or lower alkyl;
• A represents C.sub.1 -C.sub.5 straight or branched chain (i) alkylene which may be substituted with an OH group or which may contain one oxygen atom forming an ether having the formula .paren open-st.CH.sub.2 .paren close-st.O.paren open-st.CH.sub.2 .paren close-st..sub.b wherein a and b are each 1 to 4 and wherein the sum of a and b is up to 5, (ii) alkenylene, or (iii) alkynylene group;
• l represents 1, n represents 1 to 3, --- represents single bond or double bond;
• Y represent N or C;
• Z represents C(B)Ar.sup.1 Ar.sup.2, CAr.sup.1 Ar.sup.2, O-CHAr.sup.1 Ar.sup.2, phenyl, naphthyl quinolyl, benzimidazolyl, benzofuranyl, benzothiophenyl, benzisoxazolyl, benzthiazolyl, imidazopyridinyl, or a group selected from the group consisting of ##STR191## wherein B represents hydrogen, hydroxy or methoxy, Ar.sup.1 and Ar.sup.2 are each independently hydrogen or a substituted or unsubstituted aryl group, wherein said substituted aryl group contains from 1 to 3 substituents, each selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, alkylcarbonyl, alkylsulfonyl, halogen, halogenated alkyl, alkylamine, nitro, cyano, hydroxy, mercapto, and alkylthio;
• R.sup.7 and R.sup.8 respectively represent hydrogen or lower alkyl, R.sup.9 represents hydrogen, lower alkyl, lower alkoxy or halogen;
• --- represents a single bond or double bond;
• and pharmaceutically acceptable salts thereof.

A dihydrotriazolo quinoxaline derivative of the formula (II):

• ##STR192## wherein R.sup.1 represents hydrogen, lower alkyl, or C.sub.3 -C.sub.5 cycloalkyl;
• R.sup.2 and R.sup.3 each independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;
• R.sup.4 and R.sup.5 each independently represent hydrogen or lower alkyl;
• J represents hydrogen, -A-B wherein A represents C.sub.1 -C.sub.5 straight or branched chain (i) alkylene, which may be substituted with an OH group or which may contain one oxygen atom forming an ether having the formula .paren open-st.CH.sub.2 .paren close-st..sub.a O.paren open-st.CH.sub.2 .paren close-st..sub.b wherein a and b are each 1 to 4 and wherein the sum of a and b is up to 5, (ii) alkenylene, or (iii) alkynylene group, and B represents halogen, --OR.sup.10 wherein R.sup.10 represents a protective group for alcohol, or -A' --CO.sub.2 L wherein L represents hydrogen or lower alkyl and A' represents a C.sub.1 -C.sub.4 straight or branched chain alkylene.