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AssigneeGlaxo Wellcome Inc.
InventorsJanet Litster Rideout, David Walter Barry, Sandra Nusinoff Lehrman, Martha Heider St. Clair, Phillip Allen Furman
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Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose. Additionally, there is disclosed the treatment of Kaposi's sarcoma with 3'-azido-3'-deoxythymidine (AZT) and the synergistic activity in the treatment of humans infected with HTLV-III of AZT and interferon as well as AZT and acyclovir and AZT and 2-amino-9-(2-hydroxyethoxymethyl)purine or an ester thereof.
A method of treating a human being who has been diagnosed as being infected with HTLV-III comprising the administration of a non-toxic, effective amount of a combination of 3'-azido-3'-deoxythymidine or its 5'-mono-, 5'-di-, or 5'-triphosphate, or a pharmaceutically acceptable salt thereof, and the compound of formula V. ##STR5## where R is H or ##STR6## wherein R.sup.0 is H, C.sub.1-16 alkyl and physiologically acceptable acid addition salts thereof.
A method of treating a human being who has been diagnosed as being infected with HTLV-III comprising the administration of 3'-azido-3'-deoxythymidine and 2-amino-9- (2-hydroxyethoxymethyl) purine to said human being.
Dependencies are inferred from the claim text.